Introduction:
A triple-quadrupole mass spectrometer, also known as QqQ, is a tandem MS method in which the first and third quadrupoles act as mass filters and the second causes fragmentation of the analyte through interaction with a collision gas—it is a radiofrequency-only quadrupole, and can be used in either SIM or scan mode. The method can be used to obtain structural information or for quantitation. For structural mass spec, a common sequence is product ion scan, precursor ion scan, and neutral loss scan, followed by selected reaction monitoring (SRM) or multiple reaction monitoring (MRM).
Model: 1. Thermo Scientific - TSQ Quantum Ultra |
Function:
A triple-quadrupole mass spectrometer is a particularly useful method for all stages of pharmaceutical development, it is a reliable option for many applications, such as clinical research, food safety, forensics, environmental, and proteomics.
Specification:
(1) Full scan acquisition resulting in the typical total ion current plot (TIC)
(2) Selected Ion Monitoring (SIM)
(3) Selected Reaction Monitoring (SRM) or multiple reaction monitoring
(MRM).